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Study Evaluations All sufferers were examined by a skin doctor and a nephrologist at enrollment and every 3 months thereafter until the 2-year mark. During the dermatologic evaluation, investigators recorded type of skin according to Fitzpatrick’s classification , eye and hair color, and sun publicity. Sun publicity was scored on the basis of occupational and leisure exposure , tanning-bed use , and residence greater than 6 months in a tropical area . All histologically motivated skin tumors before and after randomization had been counted. Sun-protection advice was provided and its importance was emphasized. During visits to the nephrology or transplantation clinic at each center, doses of immunosuppressive medications were recorded, along with the patient’s background of acute organ rejection.