The volunteers did not know if they were acquiring nicotine or the placebo. They were only told they were taking pills that could contain caffeine, sugars, ginseng, chamomile, theobromine, kava or nicotine. ‘We attemptedto develop conditions in which people could figure out how to understand the subtle mood-altering effects of very low doses of nicotine, with the purpose of uncovering the reinforcing ramifications of nicotine,’ Griffiths explained. Apart from noting reactions , all participants were asked to try to identify when they were consuming dummy supplements and when these were consuming actual nicotine.The scholarly research was conducted relative to the International Meeting on Harmonisation guidelines, applicable regulations, and the concepts of the Declaration of Helsinki. The study protocol was approved by the independent ethics committee or institutional review board at each scholarly study site. The study was designed jointly by the study investigators and the sponsor . The investigators gathered the data, and the sponsor executed the data analyses.